Testosterone blend ® – synthetic steroid antigestagens means (blocks the action of progesterone at the receptor level), progestin activity is not. Marked antagonism with glucocorticosteroids (GCS) (due to competition on the level of communication with the receptors). It increases the contractility of the myometrium, stimulating the release of interleukin-8 in horiodetsidualnyh cells, increasing the sensitivity of the myometrium to prostaglandins. Depending on the phase of the menstrual cycle causes inhibition of ovulation, endometrial changes in and prevents implantation of a fertilized egg. Following a single dose of 600 mg maximum serum concentration of 1.98 mg / l is reached after 1.30 hours. The absolute bioavailability is 69%. The connection to plasma proteins (albumin and alpha 1-acid glycoprotein) amounts to 98%. After the first phase of the distribution of elimination is slow, the concentration is reduced 2-fold between 12-72 hours, then more rapidly. The half-life is 18 hour.
Emergency (postcoital) contraception (after unprotected intercourse or if the applied method of contraception can not be considered reliable).
A history of hypersensitivity to mifepristone, adrenal insufficiency and long-term glucocorticoid therapy, acute and chronic renal and / or hepatic insufficiency, the presence of severe extragenital pathology.
Precautions : impaired hemostasis (including previous treatment with anticoagulants), chronic obstructive lung disease (including asthma), severe arterial hypertension, cardiac arrhythmias, heart failure.
Use during pregnancy and lactation
The drug should not be used during pregnancy. Breastfeeding should be discontinued for 14 days after administration Testosterone blend®.
Dosing and Administration
Inside, within 72 hours after unprotected sexual intercourse contraception, Testosterone blenda® 1 tablet of 10 mg. To preserve the contraceptive effect it is necessary to refrain from eating for 2 hours before use of the drug and 2 hours after it. Testosterone blend ® may be used in any phase of the menstrual cycle.
Feeling of discomfort in the abdomen, weakness, headache, nausea, vomiting, dizziness, rash, pyrexia, bloody discharge from the genital tract, menstrual disorders.
reception Testosterone blenda at doses up to 2 g does not cause unwanted reactions. In cases of overdose adrenal insufficiency may occur.
Interaction with other medicinal products and other forms of interaction
Avoid the use of non-steroidal anti-inflammatory drugs.
Testosterone blend ® is not recommended for regular use as a planned, permanent contraception. Testosterone blend ® does not protect against sexually transmitted diseases and AIDS through.
In 1 or 2 tablets in blisters and 1 or 2 tablets in a jar polymer on the contour cellular packaging 1 or can together with instructions for use placed in a pile of cardboard.
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