Testosterone blend 400 administration ® – synthetic steroid antigestagens means (blocks the action of progesterone at the level of receptors), progestin activity is not. Marked antagonism with corticosteroids (due to competition on the level of communication with the receptors). A key role in the pathogenesis of uterine leiomyoma play sex hormones, particularly progesterone. The use of progesterone as a blocker of the progesterone receptor may contribute to both the inhibition of tumor growth and reduction of fibroids and uterine size.
After oral administration, maximum concentration is reached after 1.3 hours.
The absolute bioavailability is 69%.
The plasma Testosterone blend 400 administration ® 98% is associated with proteins:. Albumin and acidic alpha1-glycoprotein
After phase distribution excretion occurs first slow, the concentration is reduced 2-fold between 12 -72 hours, then more rapidly.
The half-life is 18 hours.
Pregnancy, lactation. A history of hypersensitivity to mifepristone, adrenal insufficiency and long-term glucocorticoid therapy, acute or chronic renal and / or hepatic impairment, porphyria, anemia, disorders of hemostasis (including previous treatment with anticoagulants), pelvic inflammatory disease, the presence of severe extragenital pathology . Submucous location of the fibroids. The size of uterine leiomyoma in excess of 12 weeks of pregnancy. Tumors of the ovaries and / or endometrial hyperplasia. The caution used in chronic obstructive lung disease (including asthma), severe hypertension, heart rhythm disturbances and heart failure.
Application of pregnancy and lactation
Pregnancy and lactation are contraindications to the use of the drug.
Dosing and Administration
Inside, a single dose of 50 mg Testosterone blend 400 administration ® (1 tablet) once. The course of treatment – 3 months.
Side effects of
menstrual disorders, amenorrhea, discomfort and lower abdominal pain, headache, nausea, vomiting, diarrhea, dizziness, pyrexia, fatigue, hives.
reception Testosterone blend 400 administration ® at doses up to 2 g does not cause unwanted reactions. In cases of overdose adrenal insufficiency may occur. Treatment is symptomatic.
Interactions with other drugs
should be avoided nonsteroidal anti-inflammatory drugs. When concomitantly with corticosteroids is necessary to increase the dose of the latter.
Patients with artificial heart valves or infective endocarditis when applying Testosterone blend 400 administration ® should be carried out preventive treatment with antibiotics.
10 tablets of 50 mg in blisters or 10, 20 or 30 tablets per polymer jar. According to 1,2,3,4 or 6 contour cell packages or jar along with instructions for use are placed in a pile of cardboard.
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