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omnadren vs sustanon Steroids 

omnadren vs sustanon

Pharmacodynamics
Omnadren vs sustanon is fazospetsifichnym cytostatic drug (antimetabolite, according to some sources – alkylating action) operating in the S phase of the cell cycle.It inhibits the growth of cells in interphase Gl – S, which is essential for the concurrent radiation therapy, as there is a synergistic sensitivity of tumor cells in the G1 phase by irradiation. Leveraging effect of the inhibitor RNA reductase – ribonukleoziddifosfatreduktazu causes inhibition of DNA synthesis. The drug has no effect on the synthesis of RNA and protein.

Pharmacokinetics
After intake of rapidly absorbed from the gastrointestinal tract. Maximum plasma concentrations of drug are achieved within 1-4 hours after ingestion. Receive write does not affect the absorption of the drug. Rapidly distributed throughout body tissues, it penetrates the blood-brain barrier. The cerebrospinal fluid is determined by 10-20%. a liquid aetsiticheskoy – 15-50% of plasma concentrations. The half-life – 3-4 hours. Partially metabolized in the liver and kidneys. 80% of hydroxyurea for 12 hours excreted in the urine, with 50% of unchanged form and in small quantities in the form of urea. The drug also appears to the airways in the form of carbon dioxide. After 24 hours, the plasma is not determined.

Indications

 

  • Chronic myelogenous leukemia
  • Polycythemia vera (erythremia)
  • Essential thrombocythemia
  • osteomyelofibrosis
  • Melanoma
  • Malignant tumors of the head and neck, except lip cancer (in combination with radiotherapy)
  • cervical cancer (in combination with radiotherapy)

Contraindications

Hypersensitivity to hydroxyurea or any-other auxiliaries, make up the drug.
Leukopenia below 2500 / uL, thrombocytopenia below 100,000 / mm.
Pregnancy and lactation.

Be wary – if hepatic and / or renal failure, anemia (must be Adjusted pre-treatment).

 

Dosing and Administration

When you select and dose in each individual case should be guided by the data of literature.
The drug is administered orally.
If difficulty swallowing the capsule, you can open, dissolve the contents into a glass of water and drink completely. However, some water-insoluble adjuvants may remain on the surface of the solution.
At the time of treatment should be sufficiently large quantity of liquid.

Solid tumors
– 80 mg / kg once a day every three days (6-7 doses).
– 20-30 mg / kg daily for 3 weeks.

Head and neck cancer, cervical cancer,
80 mg / kg once a day, every third day, in combination with radiation therapy.
Treatment with begin at least 7 days prior to radiation therapy and continue during radiation therapy. After radiation therapy continue to take the drug indefinitely under strict observation of the patient, and if he has no unusual or severe reactions toxicity.

Resistant chronic myelogenous leukemia
continuous therapy. From 20 to 30 mg / kg daily once a day.
Evaluation of efficacy is performed after 6 weeks of treatment. When expressed clinical remission treatment may be continued indefinitely. Treatment should be stopped if the white blood cell count less than 2500 / microliter and platelets less than 100,000 / microliter. After 3 days, a blood test is conducted repeatedly. Treatment is resumed when the content of white blood cells and red blood cells begins to increase significantly.

Polycythemia
Treatment started with a daily dose of 15-20 mg / kg. Dose set individually, seeking to maintain a hematocrit level below 45%, and the number of platelets – less than 400,000 cells / mm. Most patients unable to achieve these indicators constantly applying Omnadren vs sustanon in a daily dose of 500 to 1000 mg.

Essential thrombocythemia
usually prescribe the drug in the initial daily dose of 15 mg / kg; then pick up a dose, which supports the platelet count at a level below 600,000 / microliter, without leading to a decrease in the number of counts below 4000 / mm.

 

Side effect

From the side of hematopoiesis: leukopenia, anemia, thrombocytopenia. On the part of the digestive system: stomatitis, bleeding gums, anorexia, nausea, vomiting, diarrhea or constipation, ulceration of the mucous membrane of the gastrointestinal tract. The increase in liver enzyme activity. With the skin side and skin appendages: makulezno-papular rash, facial erythema, and peripheral erythema, dermatitis, myositis skin changes. In some cases, as a result of daily use of the drug for several years we have been observed in patients with hyperpigmentation, erythema, atrophy of skin and nails, desquamation, violet papules. In rare cases, there is alopecia, skin cancer. From the nervous system: headache, dizziness, fatigue, drowsiness, disorientation; rarely – hallucinations and convulsions. From the urinary system: an increase in uric acid, blood urea nitrogen and creatinine in the blood plasma, urine retention, interstitial nephritis. In rare cases, there is dysuria. Other: chills, malaise, increased erythrocyte sedimentation rate, allergic skin reactions, impaired fertility (azoospermia, cessation of menstruation). In rare cases reported of acute pulmonary reactions associated with the use of the drug: diffuse infiltration of the lungs, fever and shortness of breath.

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